The invention relates to an automatic comb handle assembling and welding machine which comprises an assembling platform, a rotary disc, a first drive mechanism, a handle moving and taking mechanism, a bottom cover moving and taking mechanism, a handle locating mechanism, a welding mechanism and a finished product output mechanism. The handle moving and taking mechanism is used for moving and taking handles to mold seats on the edge of the rotary disc. The handle locating mechanism is used for rotating the handles into the state that through holes in the upper ends of the handles are aligned with tubular bodies on bottom covers. The bottom cover moving and taking mechanism is used for moving and taking the bottom covers to the positions above the mold seats and arranging the bottom covers in upper ports of the handles. The welding mechanism is used for ultrasonically welding the bottom covers and the handles. Compared with a manual assembling process in the prior art, the automatic comb handle assembling and welding machine is convenient to use, and the assembling efficiency of the comb handles is greatly improved; due to the fact that the whole process is automatically operated and controlled for operation through a master control program, influences caused by manual factors are reduced, the handles and the bottom covers are accurately aligned, welding is firm, the comb handles produced in the same batch are high in quality stability, the production cost of the comb handles is reduced to a great extent, and the productive profit of an enterprise is improved.