The invention discloses a device and method for squeezing rice wine.The device comprises a differential pressure extraction separator, an extraction feeding buffer tank and a ceramic microfiltration membrane filter.A high speed flow is formed by high-pressure difference in instantaneous time through vacuum-pressurization-vacuum cyclic changes, the wine body in distilled grain is in full contact with a solvent (mellow rice wine) and is dissolved, so that wine in win residue is extracted; after solid-liquid separation, physical separation is performed through the ceramic microfiltration membrane filter, and the whole squeezing process is accompanied with a sterilization and turbidity removal process, so that the rice wine brewing process is integrated better.