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发明授权
CN105726458B 温度敏感型可溶性微针及其制备方法 有权 转让

温度敏感型可溶性微针及其制备方法
摘要：
本发明涉及一种温度敏感型可溶性微针及其制备方法。所述微针包括针尖和基层，所述针尖由温度敏感型材料和高分子赋形材料制备而成，所述基层由高分子材料制备而成；所述温度敏感型材料由材料A与材料B组成；所述材料A选自壳聚糖、聚乙烯醇、甲基纤维素或羟丙基甲基纤维素中的一种或几种；所述材料B选自β‑甘油磷酸钠、弹性蛋白多肽、泊洛沙姆184、泊洛沙姆188、泊洛沙姆407中的一种或几种；材料A与材料B的质量比为1:1‑20；所述温度敏感型材料与高分子赋形材料的质量比为1:1～10。该微针在皮肤内能够快速溶解，减少了微针对皮肤的刺激性，能够更加安全有效地释放药物。
摘要（英）：

The invention relates to a temperature-sensitive soluble microneedle and a preparation method thereof.The microneedle comprises a needle tip and a base layer, the needle tip is prepared from a temperature-sensitive material and a macromolecular shaping material, and the base layer is prepared from a macromolecular material; the temperature-sensitive material is composed of a material A and a material B, wherein the material A is selected from one or more of chitosan, polyvinyl alcohol and methylcellulose or hydroxypropyl methyl cellulose, the material B is selected from one or more of beta-sodium glycerophosphate, elastic protein polypeptides, poloxamer 184, poloxamer 188 and poloxamer 407, and the mass ratio of the material A to the material B is 1:(1-20); the mass ratio of the temperature-sensitive material to the macromolecular shaping material is 1:(1-10).The microneedle can be quickly dissolved in the skin, therefore, irritation of the microneedle to the skin is reduced, and medicine can be more safely and effectively released.

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