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CN105753991B 一种抗胎盘样硫酸软骨素的嵌合抗原受体及其应用 有权 转让

一种抗胎盘样硫酸软骨素的嵌合抗原受体及其应用
摘要：
本发明涉及肿瘤的细胞免疫治疗领域，尤其涉及一种抗胎盘样硫酸软骨素(pl‑CS)的嵌合抗原受体及其应用，所述嵌合抗原受体主要包括抗pl‑CS的抗原识别区、铰链区、跨膜区和胞内区串联构成；其中，所述抗pl‑CS的抗原识别区为疟原虫蛋白VAR2CSA、疟原虫蛋白VAR2CSA的部分肽段或pl‑CS抗体中的任意一种；所述疟原虫蛋白VAR2CSA的部分肽段为疟原虫蛋白VAR2CSA中的氨基酸数量大于500的肽段。本发明表达此嵌合抗原受体的T细胞能最大程度的杀伤肿瘤细胞，对正常组织的伤害程度很小，能突破肿瘤免疫抑制微环境，从而对实体瘤具有更好的疗效，且几乎能治疗各种类型的肿瘤。
摘要（英）：

The invention relates to the field of cellular immunotherapy of tumors, in particular to a chimeric antigen receptor resistant to placenta chondroitin sulfate (p1-CS) and application of the chimeric antigen receptor.The chimeric antigen receptor is mainly formed by serially connecting an antigen recognition area resistant to pl-CS, a hinge area, a transmembrane area and an intracellular area, the antigen recognition area resistant to p1-CS is one of plasmodium protein VAR2CSA, part of peptide segment of the plasmodium protein VAR2CSA or p1-CS antibody, and the peptide segment of the plasmodium protein VAR2CSA is a peptide segment with number of amino acid in the plasmodium protein VAR2CSA greater than 500.T cells expressing the chimeric antigen receptor can kill tumor cells to maximum extent, are quite low in degree of damage to normal tissue, can break tumor immune to inhibit microenvironment so as to have better treatment effect on solid tumors and can almost treat tumors of various types.

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