The invention belongs to the field of nuclear fuel reprocessing. In order to solve the problems of relatively low concentration levels of plutonium purification and plutonium circulation and relatively poor safety of an existing Purex process adopting no salt to restore a reagent, the invention provides a plutonium purification circulation process adopting (hydroxyamino) acetic acid as a reverse extraction reagent. The process comprises the following indexes: the concentration of 2BX (hydroxyamino) acetic acid is 0.5 to 0.8 mol/L; the concentration of 2BF plutonium nitrate is 8 to 15g/L; the concentration of 2BS nitric acid is 0 to 0.5 mol/L; the concentration multiple is 3 to 6 times; the reverse extraction series is greater than 9, and the supplementary extraction series is 3 to 5. By adopting the plutonium purification circulation process, plutonium concentration in a reverse extraction process can be increased by 5 times or more than 5 times, maximum plutonium concentration of obtained plutonium product liquid can reach 70 g/L, and higher plutonium yield and good uranium removal effect are achieved; the operational stability in a process condition range is good; better economy is obtained.