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发明公开
CN105770899A 一种大剂量药物的速释制剂及其制备方法 无效 - 驳回

一种大剂量药物的速释制剂及其制备方法
摘要：
本发明公开了一种大剂量药物的速释制剂，由活性成分和含高亲水辅料的速释基质组成，其中所述速释基质，由以下重量百分比的组分制备而成：高亲水性辅料10～30％，表面活性剂0.05～0.4％，高分子聚合物0.1～15％，其余为溶剂。本发明的速释制剂可以在服用后即可在口腔快速崩解分散，不会造成崩解困难；由于特定的速释基质与3D打印技术可以达到大剂量用极少的辅料完成制剂成型，提高载药量，活性成分可按照计算机模拟进行释放，生产工艺绿色环保，提高生物利用度。
摘要（英）：

The invention discloses a quick release agent of large-dose medicine.The quick release agent is composed of an active ingredient and a quick release matrix containing high-hydrophily auxiliary materials.The quick release matrix is prepared from, by weight, 10% to 30% of high-hydrophily auxiliary materials, 0.05% to 0.4% of surface active agent, 0.1% to 15% of high-molecular polymer and the balance solvent.The quick release agent can be fast disintegrated and dispersed in the oral cavity after being taken, and disintegration difficulty cannot be caused.Due to the specific quick release matrix and the 3D printing technology, the preparation can be formed by the large-dose medicine through few auxiliary materials, the medicine loading capacity is improved, the active ingredient can be released according to computer simulation, the production process is environmentally friendly, and bioavailability is improved.

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