利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN105801336A 一种应用三氟乙酸钯合成医药中间体菲化合物的方法 无效 - 撤回

一种应用三氟乙酸钯合成医药中间体菲化合物的方法
摘要：
本发明涉及一种应用三氟乙酸钯合成下式(I)所示菲化合物的方法，所述方法包括：惰性气氛下，在含三氟乙酸钯的催化剂、有机配体和碱存在下，于溶剂中，下式(II)化合物与式(III)化合物发生反应，从而得到式(I)化合物；其中，R1、R2各自独立地为H、C1?C6烷基、C1?C6烷氧基或卤素；R3为C6?C10芳基或C5?C8杂芳基，所述C6?C10芳基或C4?C8杂芳基任选被1?3个取代基取代，所述取代基为C1?C6烷基或卤素。所述方法通过合适催化剂、有机配体、碱和溶剂的选择而取得了良好的效果，具备广泛的工业应用前景。
摘要（英）：

The invention relates to a method for synthesizing a phenanthrene compound shown in the formula (I) in the specification from palladium trifluoroacetate. The method comprises steps as follows: a compound in the formula (II) and a compound in the formula (III) are subjected to a reaction in a solvent in an inert atmosphere in the presence of a catalyst containing palladium trifluoroacetate, an organic ligand and alkali, and the compound in the formula (I) in the specification is obtained, wherein each of R1 and R2 is independently H, C1-C6 alkyl groups, C1-C6 alkoxy groups or halogens, R3 is C6-C10 aryl groups or C5-C8 heteroaryl, C6-C10 aryl groups or C4-C8 heteroaryl are optionally substituted by 1-3 substituent groups, and the substituent groups are C1-C6 alkyl groups or halogens. The method has a good effect through proper selection of the catalyst, the organic ligand, alkali and the solvent and has wide industrial application prospect.

0/0