The invention provides an adjustment method of a variable flow line vector of a thick-bed oil deposit. The adjustment method comprises the following steps: step 1, researching the heterogeneity of a reservoir stratum; step 2, establishing a numerical simulation model, and performing history matching; step 3, researching the distribution law of remaining oil saturation; step 4, designing adjustment schemes of variable flow lines of a well pattern; step 5, predicting the ultimate recovery rates of variable flow line schemes through a numerical simulation technology, and according to the ultimate recovery rates, performing optimization of the variable flow line schemes; step 6, optimizing waterflooding parameter vectors, and through the numerical simulation technology, predicting the ultimate recovery rates of vector waterflooding parameter optimization schemes. The adjustment method of the variable flow line vector of the thick-stratum oil deposit is high in practicality, the progressive decrement of the yield and the increment of the water content of the thick-stratum oil deposit at an extra-high water cut period can be effectively alleviated, and water drive development effects are improved.