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发明公开
CN105837675A 一组阳离子抗菌肽及其制备方法 有权 转让

一组阳离子抗菌肽及其制备方法
摘要：
本发明属于医药领域，具体涉及一组阳离子抗菌肽及其制备方法。本发明在pep-05的基础上改进得到了一系列HRP5类似物，所涉及的阳离子抗菌肽的通式为Xaa1- Xaa2- Xaa3- Xaa4- Xaa5- Xaa6- Xaa7- Xaa8- Xaa9- Xaa10-Leu- Xaa12- Xaa13- Xaa14。本发明采用固相化学合成技术制备上述线性多肽。本发明制备的阳离子抗菌肽可应用于制备抗大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌、枯草芽孢杆菌、白色念球菌、耐药鲍曼不动杆菌和耐药铜绿假单胞菌的药物。
摘要（英）：

The invention belongs to the field of a medicine, and specifically, relates to a group of cationic antibacterial peptide and a preparation method thereof. According to the invention, the improvement is carried out based on pep-05 to obtain a series of HRP5 analogs. The cationic antibacterial peptide has the general formula being Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Leu-Xaa12-Xaa13-Xaa14. The cationic antibacterial peptide is the linear polypeptide and is prepared through solid-phase chemical synthesis. The cationic antibacterial peptide is applicable to prepare medicines for resisting escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, bacillus subtilis, candida albicans, drug-resistant acinetobacter baumannii, and drug-resistant pseudomonas aeruginosa.

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