The invention discloses a hoisting mechanism of a crane. The hoisting mechanism comprises a supporting frame, a winding drum set, a bearing pedestal, a bearing pedestal support, a speed reducer and a speed reducer support; the speed reducer is mounted on the speed reducer support which is supported on the supporting frame, an output shaft of the speed reducer is connected with one end of the winding drum set through a winding drum coupler, and a bolt pair is arranged between the winding drum coupler and the winding drum set; the other end of the winding drum set is supported on the bearing pedestal, and the bearing pedestal is connected with the bearing pedestal support; and the bearing pedestal support is fixed to a supporting frame through the bolt pair, and the lowest end of the connected winding drum set is higher than the upper plane of the supporting frame. According to the hoisting mechanism, dismounting and mounting of the winding drum set of the mechanism are convenient and easy, workloads are small, the assembling difficulty is small, and the mechanism is accurate and easy to control; the overhauling work time of crane winding drums is greatly shortened, the workloads of the crane winding drums are greatly reduced, and therefore the maintaining cost of the crane is greatly reduced.