The invention belongs to the technical field of pharmaceutical production, discloses plant essential oil having an anti-acne activity, and provides slow-release cream prepared from the essential oil and a preparation method of the slow-release cream. The slow-release cream is prepared from active ingredients of the plant essential oil extracted from a new variety of plant, namely borneol camphor tree, and is matched auxiliary material matrixes including castor oil, liquid paraffin, PEG-30 dipolyhydroxystearate, glyceryl monostearate, EDTA-2Na, glycerol and water. Compared with the prior art, the borneol camphor essential oil has novel ingredients and mild efficacy, the prepared slow-release cream has the characteristics of being long-lasting in effect, small in toxic or side effects, convenient for a user to use and the like, and the clinical effects of the acne cream is effectively guaranteed.