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发明公开
CN105968009A 5-异丙基-9-羟基-8-甲基-6-壬烯-2-酮草酸双酯及其合成方法与应用 有权

5-异丙基-9-羟基-8-甲基-6-壬烯-2-酮草酸双酯及其合成方法与应用
摘要：
本发明公开了一种5‑异丙基‑9‑羟基‑8‑甲基‑6‑壬烯‑2‑酮草酸双酯及其合成方法与应用，将茄酮溶于无水苯中，加入乙二醇和对甲基苯磺酸，反应后得到茄酮缩乙二醇，将茄酮缩乙二醇溶于无水THF，滴加甲硼烷四氢呋喃络合物、NaOH溶液和过氧化氢，反应得到5‑异丙基‑9‑羟基‑8‑甲基‑6‑壬烯‑2‑酮缩乙二醇，将其溶于无水CH2Cl2，加入三乙胺和草酰氯，室温下反应3.5h，得到5‑异丙基‑9‑羟基‑8‑甲基‑6‑壬烯‑2‑酮草酸双酯，将其应用于卷烟加香中的作用主要是提高香气质和香气量，降低刺激性，纯净余味。
摘要（英）：

The invention discloses bis(5-isopropyl-9-hydroxyl-8-methyl-6-nonylene-2-one) oxalate as well as a synthesis method and application thereof. The synthesis method comprises the following steps: dissolving solanone in anhydrous benzene; adding ethylene glycol and p-toluene sulfonic acid; reacting to obtain solanone ethylene glycol condensate; dissolving the solanone ethylene glycol condensate in anhydrous THF; dropwise adding a borane tetrahydrofuran complex, a NaOH solution and hydrogen peroxide; reacting to obtain 5-isopropyl-9-hydroxyl-8-methyl-6-nonylene-2-one ethylene glycol condensate; dissolving the 5-isopropyl-9-hydroxyl-8-methyl-6-nonylene-2-one ethylene glycol condensate in anhydrous CH2Cl2; adding triethylamine and oxalyl chloride; and reacting for 3.5h at room temperature to obtain the bis(5-isopropyl-9-hydroxyl-8-methyl-6-nonylene-2-one) oxalate. The bis(5-isopropyl-9-hydroxyl-8-methyl-6-nonylene-2-one) oxalate is applied to cigarette flavoring and mainly used for increasing the aroma quality and aroma quantity, reducing the irritation and purifying the aftertaste.

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