The invention discloses palatability florfenicol powder and a preparation method thereof. The palatability florfenicol powder is prepared from, by mass, 1%-30% of florfenicol, 0.1%-1% of sodium alginate, 0.1%-0.8% of sodium bicarbonate, 0.01%-0.05% of lemon yellow and 80%-90% of starch. The florfenicol powder is good in palatability and has an antibacterial property on escherichia coli and staphylococcus aureus; the stability is good, the seven-day performance at 40 DEG C is unchanged, and the performance is unchanged on the condition that ultraviolet irradiation is conducted for 48 h at 40 DEG C. In addition, the preparation technology is simple, the raw materials are low in price and easy to obtain, the cost is low, the performance is stable, and the florfenicol powder is suitable for industrial large-scale production; florfenicol is a widely applied veterinary medicine, and therefore the florfenicol powder has a wide application prospect.