The invention discloses a method and device for estimating wound area and relates to the field of medical equipment. The device comprises an image recognition module used for recognizing a 2D scale image from a captured image; a scale determining module for determining a proportion of the image to an actual dimension by using the recognized 2D scale image; an image clustering module for clustering the captured image according to colors to obtain multiple types of wound images corresponding to different types of tissue components; and an area computing module for estimating the wound area of different tissue components by using the proportion of the image to the actual dimension and the multiple types of wound images corresponding to the different types of tissue components. The method and device may automatically, rapidly, and accurately provide the area information of the whole wound and the area information of different components of the wound, are easy to operate and high in computational precision.