The invention relates to a method for preparing nanometer micro-encapsulated cold-water dispersion type powder with lycopene. The method includes sufficiently dissolving and homogenizing the lycopene, compound non-ionic surfactants and the like by the aid of nontoxic solvents to obtain nanoscale substances; adding excipient wall materials into the nanoscale substances and uniformly mixing the excipient wall materials and the nanoscale substances with one another; uniformly distributing the nanometer lycopene in the wall materials in molten states; carrying out spray drying or vacuum drying and then smashing the wall materials with the nanometer lycopene to obtain the micro-capsule powder. The method has the advantages that the content of the lycopene in the micro-capsule powder can reach 10% at least, the lycopene is embedded by the excipient wall materials, accordingly, the stability of the lycopene can be greatly improved, the nanometer micro-encapsulated cold-water dispersion type powder can be dispersed by the aid of cold water, and emulsion is in a transparent or semi-transparent state and is quite stable; the lycopene is subjected to nanoscalization and can be advantageously absorbed by human bodies, the bioactivity can be obviously improved, and the method can be widely applied to the field of the food industry and the aspects such as medical healthcare soft and hard capsules, tablets and micro-emulsion.