The invention relates to the technical field of medicine dispensing equipment, in particular to an automatic medicine dispensing machine. The automatic medicine dispensing machine comprises a bottom plate, a medicine dispensing layer structure, a transmission mechanism and medicine dispensing devices. The medicine dispensing layer structure is provided with a plurality of medicine groove units, a pulley assembly is installed under the medicine outlet end of each medicine groove unit, and the pulley assemblies are in transmission connection with a driving shaft through belts. The medicine outlet end of each medicine groove unit is provided with the corresponding medicine dispensing device in butt joint with the corresponding pulley assembly. Driven shafts in an existing medicine dispensing machine are improved into the independent pulley assemblies correspondingly installed at the medicine groove units, each pulley assembly is provided with an upper pulley and a lower pulley which are arranged in the vertical direction, the medicine dispensing devices are installed close to the pulley assemblies as much as possible, and the gaps between the medicine dispensing devices and the upper ends of the butt-joint positions of the pulley assemblies are much smaller than the gaps between the driven shafts and the butt-joint positions of the medicine dispensing devices in the prior art, so that the technical problem that medicine boxes are prone to getting stuck when passing through the butt-joint positions is solved.