The invention discloses a frame folding mechanism for a manned moon rover. A front frame and a rear frame are of the same structure and are symmetrically arranged with respect to a middle frame. Both the front frame and the rear frame are hinged to the middle frame so that the front frame and the rear frame can be folded oppositely. Middle wheels are symmetrically mounted on the left side and the right side of the middle frame. Front wheels are symmetrically arranged on the left side and the right side of the front end of the front frame. Rear wheels are symmetrically arranged on the left side and the right side of the rear end of the rear frame. The front wheels and the rear wheels are hinged to suspensions on the corresponding frames so that the front wheels and the rear wheels can swing upwards in the pitching direction. When the front frame and the rear frame are oppositely folded in place, each front wheel and the rear wheel on the corresponding side are attached together. According to the frame folding mechanism for the manned moon rover, the frames and a moving system can be highly folded, the folding ratio of the manned moon rover is effectively increased, and the initial storage volume of the manned moon rover in the launching process is reduced; the frame folding mechanism has the characteristics of being reasonable in design, easy to implement, low in cost and the like; and folding is easy, convenient and fast, and the whole manned moon rover is regular and attractive in appearance and convenient to carry after being folded.