The invention discloses a zoom pick-up lens based on liquid lenses and a pick-up instrument comprising the same. The zoom pick-up lens based on liquid lenses comprises a first fixed lens group with negative focal power, a first focusing group, a second fixed lens group with positive focal power, a third fixed lens group with positive focal power, a fourth fixed lens group with negative focal power, a second focusing group and a fifth fixed lens group with positive focal power, which are arranged in sequence from an object side to an image side, wherein the first focusing group and the second focusing group are respectively provided with a liquid lens; the first fixed lens group, the second fixed lens group, the third fixed lens group and the fourth fixed lens group are all composed of spherical lenses; and the lens surfaces on the object side and the image side of the fifth lens group are aspheric lenses.