The invention discloses a preparation method of a multipolymer artificial cornea. The method comprises the steps that 1, a multi-component copolymerization material is synthesized, wherein multiple monomer materials are taken and mixed, a catalyst is added, vacuumizing is conducted, nitrogen is charged, a reaction is conducted in a sealed vessel, and the multipolymer is prepared; 2, a cornea three-dimensional scaffold is prepared, wherein a 3D bio-printer is used, the multipolymer serves as the raw material, and a cornea-shaped three-dimensional scaffold is printed; 3, functional modification is conducted on the scaffold by means of ECM, wherein decellularized porcine cornea extracellular matrix dry powder is taken and dissolved in distilled water, and extracellular matrix particles in a suspension uniformly cover the surface of the cornea three-dimensional scaffold; 4, a residual cornea micro organization method is established; wherein a cornea of a patient is taken for micro organization treatment and then injected into a modified scaffold material, and the artificial cornea which is excellent in mechanical property and good in biocompatibility is obtained through preparation.