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发明公开
CN106167824A 与老年性骨质疏松相关微小RNA的寡核苷酸化合物的应用 无效 - 驳回

与老年性骨质疏松相关微小RNA的寡核苷酸化合物的应用
摘要：
本发明公开了一种与老年性骨质疏松相关微小RNA的寡核苷酸化合物的应用，用于弥补基于微小RNA的寡核苷酸在制备促进成骨细胞功能、抑制老年性骨质疏松症化合物应用中的空缺。技术方案是筛选获得与老年性骨质疏松相关的微小RNA，通过合成基于与老年性骨质疏松相关微小RNA的寡核苷酸并转染至前成骨细胞和老年骨质疏松小鼠体内，结果显示可促进成骨细胞功能，并抑制老年性骨质疏松症的进展。本发明制备的基于与老年性骨质疏松相关微小RNA的寡核苷酸，可通过促进成骨细胞功能，抑制老年性骨质疏松症的程度，弥补了基于微小RNA的寡核苷酸在制备促进成骨细胞功能、抑制老年性骨质疏松化合物应用中的空缺。
摘要（英）：

The invention discloses an application of an oligonucleotide compound of micro-RNA (ribonucleic acid) associated with senile osteoporosis. The oligonucleotide compound is used for filling in the gap of micro-RNA based oligonucleotide in application of preparing the compound for promoting osteoblast functions and inhibiting the senile osteoporosis. The technical scheme includes that the micro-RNA associated with the senile osteoporosis is obtained by screening, the oligonucleotide based on the micro-RNA associated with the senile osteoporosis is synthesized and transfected to into preosteoblast and senile osteoporosis mice bodies, results indicate that the osteoblast functions can be promoted, and the progress of the senile osteoporosis is inhibited. The prepared oligonucleotide based on the micro-RNA associated with the senile osteoporosis can inhibit the degree of the senile osteoporosis by promoting the osteoblast functions, and the gap of the micro-RNA based oligonucleotide in application of preparing the compound for promoting the osteoblast functions and inhibiting the senile osteoporosis is filled in.

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