The invention belongs to the technical field of pharmaceutical chemistry, particularly relates to an R type isomer of a medicine compound N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfinyl) ethylamino) methyl)-2-furanyl)-quinazoline-4-amine, xylenesulphonate (as shown in a formula II) of the R type isomer, and a polymorphic substance of the xylenesulphonate, and particularly discloses a preparation method of the R type isomer, a preparation method of the xylenesulphonate and a preparation method of the polymorphic substance. Biological test data indicates that the R type isomer compound and the xylenesulphonate thereof provided by the invention both show good restraining activity for EGFR and Her2 tyrosine kinase, and particularly the crystal form A of a compound as shown in the formula II obviously has good absorption quantity and good exposure quantity.