The invention innovatively discloses a manual four-claw two-linkage self-centering chuck. The manual four-claw two-linkage self-centering chuck is characterized in that the manual four-claw two-linkage self-centering chuck comprises a chuck body with a hole formed in the center and two gear shafts installed on the chuck body in a penetrating manner and capable of rotating; the front side of the chuck body is provided with rolling wheel assemblies forming four clamping claws and two groove wheel disks installed on the back side of the chuck body in a front and back staggered manner; the gear shafts are correspondingly in transmission connection with the groove wheel disks; inclined grooves are formed in the two ends of each groove wheel disk in a 180-degree symmetry manner; the inclined grooves are each internally provided with a rolling wheel; the rolling wheel assemblies are connected with the rolling wheels through sliding blocks and rolling wheel shafts; and the sliding blocks are installed in guiding blocks on the surface of the chuck body. The manual four-claw two-linkage self-centering chuck is composed of the gear shafts installed on the chuck body, the groove wheel disks driving the rolling wheel assemblies to synchronously move in opposite directions and the like; by manually rotating the gear shafts, the corresponding rolling wheel assemblies can achieve centering synchronous linear motion, and clamping and positioning of various workpieces symmetrical about the center axis are achieved; and the structure is simple and reasonable, the operating process is simple and convenient, and using is convenient and stable.