The invention discloses a method for detonation fracture acidizing combined operation. The method comprises the steps of optimizing detonation fracture acidizing combined operation process parameters, performing operation preparation before detonation fracture and filling a pitshaft with liquid, testing stratum absorption amount before the detonation fracture, placing a detonation fracture operation tubular column to a predetermined operation depth, performing pressurization detonation of the tubular column, performing well killing operation, detonating the fracture operation tubular column, testing the stratum absorption amount after the detonation fracture, placing an acidizing operation tubular column, performing pumping injection acid liquid slug, lifting the acidizing operation tubular column, placing an electric pump production tubular column and performing electric pump liquid drainage and well opening alkalifying neutralization, placing an electric pump production Y tubular column without a Y tubular column, performing pumping injection of acid liquid slug, placing the Y tubular column, performing electric pump liquid drainage and well opening alkalifying neutralization and the like. The method has the advantages that detonation fracture and acidizing effects can be further enhanced, the acid liquid injection capability is enhanced, the acidizing radius is expanded, crack closure is further avoided, and a physical effect is enhanced; a detonation fracture effect can be enhanced, a follow-up acidizing step is selected flexibly, and the operation step is omitted while an operation effect can be guaranteed.