The invention provides a pipeline pressure reduction device. The device comprises an inner core cylinder and a shell, one end of the inner core cylinder is an opening end, the other end of the inner core cylinder is a closing end, the two ends of the shell are opening ends, the inner core cylinder and the shell are different in inner diameter, the inner core cylinder is coaxially inserted in the shell, the opening end of the inner core cylinder is in abut joint with a high-pressure pipeline, and the outer wall of the opening end of the inner core cylinder and one end of the shell are arranged in a sealed manner; a supporting frame is arranged at the closing end of the inner core cylinder, and is fixedly connected with the other end of the shell, and a plurality of throttling nozzles are formed in the wall of the inner core cylinder in the radial direction. The device is high in pressure reduction capacity, and single-stage pressure reduction can reach 35 MPa; the low(pressure) control precision is high, adjustment is convenient, according to the flow and the inlet and outlet pressure difference, the mounting number of the throttling nozzles is determined, it can be ensured that the flow control precision is superior to 5%, for different stations, only the number of the nozzles needs to be adjusted, and the device is convenient and rapid.