The invention relates to a front multi-pollutant oxygen spraying cooperative control system and method. In the system, an oxidation additive spraying system is additionally installed on a desulfurization tower inlet flue duct, a liquid oxidant is sprayed into the flue duct, NO and gas-state Hg<0> in flue gas are oxidized, NO2 and Hg<2+> which are prone to be dissolved in desulfurization tower slurry are generated, and cooperative control over multiple pollutants is achieved; on one hand, under the flue gas condition of 85 DEG C to 120 DEG C, the liquid oxidant is fully mixed with NO and gas-state Hg<0> in the flue gas and oxidized through volatilization, and the good oxidation efficiency can be achieved; on the other hand, the liquid oxidant is mixed with and makes contact with NO and gas-state Hg<0> in the flue gas in the spraying process, and the oxidation efficiency of NO and gas-sate Hg<0> in the flue gas is further improved; the sprayed liquid oxidant additive returns to an additive preparation tank through a circulation device, and circulating utilization is achieved. The flue gas obtained after NO and Hg<0> are oxidized enters a desulfurization tower, and by means of desulfurization tower slurry spraying, cooperative removal of multiple pollutants is achieved.