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发明公开
CN106344499A 一种FTY720滴眼液及其制备方法和用途 无效 - 驳回

一种FTY720滴眼液及其制备方法和用途
摘要：
本发明公开了一种FTY720滴眼液及其制备方法和用途。本发明的FTY720滴眼液，每升含FTY720 1-5g、磷酸氢二钠15.35g、磷酸二氢钠4.14g、氯化钠0.5g、苯扎氯铵0.1g和余量的注射用水，pH值为6.0-7.5，渗透压为280-320mOsmol/kg；其制备方法为：取适量注射用水，加入磷酸氢二钠、磷酸二氢钠、氯化钠和苯扎氯铵，使全溶；然后加入FTY720溶解，再加注射用水补足体积；过滤除菌后得到FTY720滴眼液。在角膜移植中，FTY720滴眼液具有很好的延长角膜植片生存期及抗排斥的效果。本发明填补了没有FTY720眼用制剂的空白，扩展了其在眼科临床的应用。
摘要（英）：

The invention discloses FTY720 eye drops and a preparation method and application thereof. Per liter of the FTY720 eye drops comprises 1-5g of FTY720, 15.35g of sodium hydrogen phosphate, 4.14g of sodium dihydrogen phosphate, 0.5g of sodium chloride, 0.1g of benzalkonium chloride and the balance water for injection, a pH value of the eye drops is 6.0-7.5, and an osmotic pressure of the eye drops is 280-320mOsmol/kg. The preparation method includes: taking an appropriate amount of water for injection, and adding sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium chloride and benzalkonium chloride to dissolve completely; adding FTY720 to dissolve, and adding the water for injection to make up the volume; filtering and sterilizing to obtain the FTY720 eye drops. In corneal transplantation, the FTY720 eye drops have great effects of prolonging growth periods of corneal grafts and resisting to rejection. By the FTY720 eye drops and the preparation method and application thereof, a gap of lack of FTY720 ophthalmic preparations is filled, and ophthalmological clinical application of the FTY720 eye drops is extended.

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