The invention disclsoes anti-oxidization health-care wine and a preparation method thereof, and belongs to the field of health-care foods. The anti-oxidization health-care wine is prepared from the following raw materials in parts by weight: 5 to 10 parts of radix cynanchi bungei, 1 to 2 parts of lepidium meyenii, 0.1 to 0.5 part of longan aril and a proper amount of Baijiu. The preparation method comprises: mixing the radix cynanchi bungei, the lepidium meyenii and the longan aril and extracting with water. The raw materials are extracted through selecting a proper extracting manner according to properties of functional components, so that the stability of the functional components is guaranteed, and a relatively high extracting rate is obtained. The health-care wine prepared by the invention has the advantages of novel food materials including the radix cynanchi bungei and the lepidium meyenii, and a traditional Chinese medicinal material longan aril, and has an anti-oxidization effect and the like.