The invention provides a static discharge protection circuit and a chip with a static discharge protection mechanism. The static discharge protection circuit comprises an input detection unit taking a floating grid structure as a basis and a static release unit. The input detection unit is used for detecting whether a static discharge phenomenon takes place on a welding pad and generating static detection signals based thereon. The static release unit receives the static detection signals from an output end of the input detection unit, and according to the static detection signals, decides to conduct a discharge path so as to transmit electric energy on the welding pad to a reference end during the static discharge phenomenon. The input detection unit establishes equivalent impedance as static detection impedance between the output end and the welding pad or the reference end, and based on the static detection impedance, generates the static detection signals for indicating whether the static discharge phenomenon takes place. The static discharge protection circuit and the chip with the static discharge protection mechanism can maintain quite good leakage current characteristics in a small-dimension circuit layout design and enable the stability of overall static discharge detection to be improved.