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发明公开
CN106389385A 一种基于环糊精及卵磷脂为载体的番荔素纳米粒及其制备方法和应用 失效 - 权利终止

一种基于环糊精及卵磷脂为载体的番荔素纳米粒及其制备方法和应用
摘要：
本发明涉及一种以环糊精以及卵磷脂为载体制备的番荔素纳米粒及其制备方法和应用。所述的番荔素(番荔素总内酯或其单体成分)纳米粒采用溶剂沉淀法制备，番荔素、环糊精、卵磷脂三者之间质量比为1∶0.02～20∶0.02～20，其最优的处方组成为番荔素、环糊精、卵磷脂的组合比例为4∶2∶1(质量比)。所述番荔素纳米粒的平均粒径20-1000nm，分散性良好；在胃肠液中及血浆中均稳定，即可口服给药，也可以静脉注射；该纳米粒显著地提高了番荔素对肿瘤细胞抑制作用，同时大大提高了体内抗肿瘤药效，具有广阔的开发前景。
摘要（英）：

The invention relates to annonaceous acetogenins nanoparticles, which are prepared by taking cyclodextrin and lecithin as vectors, as well as a preparation method and an application of annonaceous acetogenins nanoparticles. The annonaceous acetogenins (annonaceous acetogenins total lactone or monomer ingredients thereof) nanoparticles are prepared by virtue of a solvent precipitation method; the mass ratio of the annonaceous acetogenins to the cyclodextrin to the lecithin is at 1 to (0.02-20) to (0.02-20); and in accordance with an optimal prescription, the combining proportion of the annonaceous acetogenins to the cyclodextrin to the lecithin is at 4 to 2 to 1 (in percentage by mass). The average grain size of the annonaceous acetogenins nanoparticles is 20-1000nm, and the annonaceous acetogenins nanoparticles are good in dispersity; the annonaceous acetogenins nanoparticles are stable in both gastrointestinal fluid and plasmid, and the annonaceous acetogenins nanoparticles are suitable for both oral administration and intravenous injection; with the application of the nanoparticles, the inhibitory effect of the annonaceous acetogenins on tumor cells can be significantly improved, and meanwhile, in vivo anti-tumor efficacy can be enhanced; and the annonaceous acetogenins nanoparticles have a broad development prospect.

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