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发明公开
CN106399267A 表达H7N9亚型禽流感病毒血凝素蛋白的重组火鸡疱疹病毒株rHOH及构建方法 无效 - 撤回

表达H7N9亚型禽流感病毒血凝素蛋白的重组火鸡疱疹病毒株rHOH及构建方法
摘要：
本发明属于分子生物学和生物技术领域的重组病毒载体疫苗，具体涉及一种表达H7N9亚型禽流感病毒血凝素蛋白的重组火鸡疱疹病毒株rHOH及构建方法。所述重组火鸡疱疹病毒株rHOH，其保藏号是CGMCC NO.12985。所述的重组火鸡疱疹病毒株rHOH，它的gB启动子来源于火鸡疱疹病毒载体FC126自身；表达的外源抗原(血凝素蛋白)基因经Gallus Gallus的密码子偏嗜性优化，核苷酸的序列发生改变，但不改任何变氨基酸序列。该重组火鸡疱疹病毒株rHOH可用于制备预防H7N9亚型禽流感病毒的疫苗；接种孵化后第18日龄的鸡胚或1日龄的雏鸡，预防和控制家禽的H7N9疫情，保护公众卫生和安全。
摘要（英）：

The invention belongs to recombinant virus carrier vaccines in the field of molecular biology and biotechnology, and particularly relates to a recombinant turkey herpesvirus virus strain rHOH expressing H7N9 subtype avian influenza virus haemagglutinin protein and a construction method. The preservation number of the recombinant turkey herpesvirus virus strain rHOH is CGMCC NO.12985. A gB promoter of the recombinant turkey herpesvirus virus strain rHOH comes from a turkey herpesvirus virus carrier FC126 itself; an expressed heterologous antigen (haemagglutinin protein) gene is optimized through codon bias of Gallus Gallus, the nucleotide sequence changes, and no amino acid sequence changes. The recombinant turkey herpesvirus virus strain rHOH can be used for preparing vaccines for preventing H7N9 subtype avian influenza viruses; 18-day-old chick embryos obtained after hatch or 1-day-old chicks are inoculated, an H7N9 epidemic situation of poultry is prevented and controlled, and public health and safety are protected.

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