A full-automatic installation and detection device for a water cooling connection is used to correspondingly install a seal ring, a check ring and a retaining fastener on a water cooling connection, and comprises: a water cooling connection conveying unit; a rotating clamping unit having a rotating disc that rotates in a certain direction, and seven rotating disc clamps for clamping a water cooling connection that are circumferentially disposed in a direction of rotation of the rotating disc from a position, corresponding to the water cooling connection conveying unit, of the edge of the rotating disc; a seal ring installing unit, a check ring installing part, an image detecting part for detecting whether the seal ring and the check ring are installed correctly, a drawing force detecting part, a sealing performance detecting part, a retaining and installing part and a qualified product transferring part that are circumferentially disposed corresponding to the seven rotating disc clamps in sequence in the direction of rotation of the rotating disc; and a control unit for controlling the above various units.