The invention provides a numerical weather prediction method based on cloud computation. According to the method, in a WRF mode system, a remote interaction parallel grid nested computing scheme is employed, computing tasks are reasonably distributed between a numerical weather prediction center and a user terminal, high-efficiency transmission and management of files among computing nodes are realized, and a numerical weather prediction configuration method based on cloud computation is obtained. The scheme is applicable to the conditions that the computing tasks of main nodes and sub-nodes are huge, the computing times are similar, and the sum of the computing times exceeds the requirement. According to the method, the computing times of the main nodes and the sub-nodes can be overlapped so that the total computing time is effectively reduced; the numerical weather prediction serves as a cloud computing service provided for development staff, the scientific research and business fields can fully utilize computing resources of a cloud computing platform, the work of numerical weather prediction is developed, the utilization rate of a high-performance computer is increased, and the calculating efficiency of the numerical weather prediction is effectively improved.