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发明授权
CN106459007B 嘧啶-2，4-二胺衍生物及包含其作为有效成分的抗癌用药学组合物 失效 - 权利终止

嘧啶-2，4-二胺衍生物及包含其作为有效成分的抗癌用药学组合物
摘要：
本发明涉及嘧啶‑2，4‑二胺衍生物或包含其药学上可接受的盐及包含其作为有效成分的癌症预防或治疗用药学组合物，本发明的化合物具有优秀的抑制间变性淋巴瘤激酶(ALK)活性的效果，由此可提高针对具有EML4‑ALK、NPM‑ALK等的间变性淋巴瘤激酶(ALK)融合蛋白的癌细胞的治疗效果，并且预期可有效地防止癌症复发，从而可有用地使用于癌症预防或治疗用药学组合物。
摘要（英）：

The present invention relates to a pyrimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for prevention or treatment of cancer comprising the same as an effective ingredient. A compound according to the present invention has the good effect of inhibiting anaplastic lymphoma kinase (ALK) activity, whereby a therapeutic effect on cancer cells having an anaplastic lymphoma kinase (ALK) fusion protein such as EML4-ALK, NPM-ALK, etc. can be enhanced and it is expected that a recurrence of cancer will be effectively inhibited. As such, the compound can be effectively used in a pharmaceutical composition for prevention or treatment of cancer.

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