The invention relates to a high-precision microscopic-positioning numerical-control micro-pore drilling device comprising a base plate. A horizontal guide rail is fixed to the base plate. A left locking module and a right locking module are fixed to the position in front of the horizontal guide rail. A perpendicular feeding module and a microscopic-positioning module are fixed to the back portion of the guide rail. A horizontal sliding block is installed on the horizontal guide rail in a sliding manner. A sliding block and sliding table connecting plate is fixed to the horizontal sliding block. A first cross-shaped sliding table is fixed to the top of the sliding block and sliding table connecting plate. A sliding table and clamp connecting plate is fixed to the top of the first cross-shaped sliding table. A clamp is fixed to the top of the sliding table and clamp connecting plate. The high-precision microscopic-positioning numerical-control micro-pore drilling device can drill micro-pores and is high in drilling precision and positioning precision, capable of achieving drilling at different points, compact in structure and convenient to operate, and the drilling technology has high flexibility.