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发明公开
CN106478659A 苯并恶唑并恶嗪酮类化合物WA1-089的晶型C及其制备方法 无效 - 撤回

苯并恶唑并恶嗪酮类化合物WA1-089的晶型C及其制备方法
摘要：
本发明涉及一种新型Xa因子抑制剂——苯并恶唑并恶嗪酮类化合物WA1-089的新晶型及制备方法，具体涉及新晶型C及其制备方法。所述晶型C的X-射线粉末衍射图中在2θ为5.35、11.00、16.00、16.24、16.89、17.95、18.64、18.89、19.35、20.71、21.01、22.91、23.39、23.85、24.63、25.68、27.00、29.69、30.19、30.81、32.07、32.92以及34.24±0.2°处具有X-射线粉末衍射峰。晶型C通过熔融结晶的方法制得，该方法具有产品纯度高、能耗低，不需要加入其它溶剂，对环境污染小等特点。
摘要（英）：

The invention relates to a novel crystal form of a novel Xa factor inhibitor, namely, a benzoxazole and oxazinone compound WA1-089 and a preparation method, in particular to a novel crystal form C and a preparation method thereof. An X-ray powder diffraction pattern of the crystal form C has X-ray powder diffraction peaks when 2theta is 5.35 degrees, 11.00 degrees, 16.00 degrees, 16.24 degrees, 16.89 degrees, 17.95 degrees, 18.64 degrees, 18.89 degrees, 19.35 degrees, 20.71 degrees, 21.01 degrees, 22.91 degrees, 23.39 degrees, 23.85 degrees, 24.63 degrees, 25.68 degrees, 27.00 degrees, 29.69 degrees, 30.19 degrees, 30.81 degrees, 32.07 degrees, 32.92 degrees and 34.24+/-0.2 degrees. The crystal C is prepared through a melt crystallization method, and the method has the advantages of being high in product purity, low in energy consumption and low in pollution to the environment, needing no other solvents and the like.

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