The invention discloses a hole sealing device applied to a carbon dioxide blasting and burst technology. The hole sealing device comprises a shell, a lead pipe, an exploder, an exploder guide wire, a high pressure liquid injection hole, a carbon dioxide liquid injection hole and a carbon dioxide liquid injection pipe, wherein the high pressure liquid injection hole, the carbon dioxide liquid injection hole and a lead pipe hole are formed in one end of the shell; the lead pipe hole communicates with the lead pipe; the lead pipe penetrates through the entire shell and stretches out of the other end of the shell; the exploder is arranged at the other end of the shell; the carbon dioxide liquid injection pipe penetrates through the entire shell; the carbon dioxide liquid injection hole communicates with the carbon dioxide liquid injection pipe; and the exploder guide wire is arranged inside the lead pipe, and is connected with the exploder. The hole sealing device has the advantages that the structure is simple, the utilization is convenient, the hole sealing effect is good, and the hole sealing device can be repeatedly utilized.