The invention discloses a pharmaceutical composition for preventing and treating comedo. The pharmaceutical composition for preventing and treating comedo consists of the following raw materials in parts by weight: 5-8 parts of oxytetracycline slices, 3-5 parts of Cortex Mori, 5-8 parts of Fructus Gardeniae, 3-5 parts of compound dexamethasone acetate cream, 3-10 parts of fluocinonide cream, 4-6 parts of loratadine tablets, 0.5-2 parts of retinoic acid, 1-3 parts of panax notoginseng saponins, 5-10 parts of honey, 1-3 parts of aloe glue, 2-5 parts of miconazole nitrate cream, 5-10 parts of olive oil and 1-3 parts of amprenavir. The pharmaceutical composition has synergistic effect by compounding of the raw materials, can effectively inhibit growth of the comedo and promote inflammation diminishing and recovery of the comedo, and can effectively remove acne marks and promote skin regeneration; and the used raw materials are easy to obtain, the cost is low, the curative effect is good, and the pharmaceutical composition is convenient to smear and small in toxic or side effects. In addition, if the pharmaceutical composition is smeared on a normal skin, the skin can be fine, smooth and elastic.