The invention discloses a spacecraft fluid path breakout connector dual-set synchronous separation device and belongs to the technical field of spacecrafts. The spacecraft fluid path breakout connector dual-set synchronous separation device comprises two sets of separation power components, a fixed base, a separation bracket, an outer guiding barrel, an inner guiding barrel, a separation nut and a connecting screw rod; the separation power components are used for providing power for separating the bracket from the fixed base; an installation plate of the separation bracket is tightly pressed on the fixed base; the inner guiding barrel is fixed into a rectangular frame body of the separation bracket, and the outer guiding barrel is installed on the outer circumferential face of the inner guiding barrel in a sleeving mode; the separation nut is installed in the inner guiding barrel, one end of the separation nut is fixed to the top of the rectangular frame body of the separation bracket, and the other end of the separation nut is connected with the connecting screw rod; and the two separation power components are symmetrically installed on the two sides of the separation nut, and the two ends of each separation power component are fixedly connected with the separation bracket and the fixed base correspondingly. The spacecraft fluid path breakout connector dual-set synchronous separation device can autonomously achieve whole translation pull-disengagement separation of cabin liquid path detachable connectors in advance before cabin section separation of a spacecraft.