The invention provides a construction process for shipping large sinking pipes by a self-propelled semi-submerged ship for transporting the sinking pipes from a sinking pipe prefabrication factory to a foundation trench region for sinking pipe mounting construction. A mooring and outfitting region is arranged next to the foundation trench region, the semi-submerged ship loads the sinking pipes in a deep dock of the sinking pipe prefabrication factory and transports the same to the mooring and outfitting region, and after an outfitting step of the sinking pipes in the mooring and outfitting region is finished, the sinking pipes are transported to the foundation trench region in a floating manner through a sinking pipe mounting ship and a tug. According to the construction process for shipping large sinking pipes by the self-propelled semi-submerged ship provided by the invention, the floating transportation distance of the sinking pipe is greatly reduced, and the work efficiency of transporting the sinking pipe to 3-4 times; secondly, as draft of the semi-submerged ship which transports the sinking pipes is smaller compared with that of sinking pipe floating transportation in the prior art, the requirement on channel depth is greatly reduced. The channel needs not to be excavated, so that the time and economical costs are further saved; furthermore, the requirements on natural conditions such as a water wave flow by transporting the sinking pipes by the semi-submerged ship are relatively low, the limiting condition of transporting the sinking pipes is reduced, and the work efficiency of transporting the sinking pipes is further improved.