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发明公开
CN106544319A 一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法 无效 - 驳回

一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法
摘要：
本发明提供了一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法，该组合物包括环二核苷酸与IFN-γ。采用该组合物能够诱导树突状细胞成熟，刺激树突状细胞持续分泌IL-12，能持续保持树突状细胞的生物学活性，能表达更高水平的MHC-II、CD40、CD80、CD86，进而能更有效地诱导T细胞的抗肿瘤免疫及抗肿瘤特异性细胞毒性T淋巴细胞反应，有助于提高树突状细胞在临床抗肿瘤等疾病治疗过程中的疗效。
摘要（英）：

The invention provides a composition for stimulating dendritic cell maturation, and a method for stimulating dendritic cell maturation. The composition comprises cyclic dinucleotide and IFN-gama. By adopting the composition, dendritic cell maturation can be induced, a dendritic cell can be stimulated to continuously secrete IL-12, the biological activity of the dendritic cell can be continuously maintained, MHC-II, CD40, CD80 and CD86 with higher levels can be expressed, and then antitumor immunity of a T cell and cytotoxic T lymphocyte reaction of an antitumor specific cell can be effectively induced, so that the curative effect of the dendritic cell during a treatment process of diseases such as clinic antitumor is improved favorably.

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