The invention relates to a benzoheterocycle derivative having [beta]2 agonist activity, a preparation method, and an application thereof, and in particularly, relates to a compound represented as the general formula (I), or a stereoisomer, a hydrate, a metabolite, a solvent, a pharmaceutically acceptable salt, a eutectic crystal, or a prodrug of the compound, and relates to the preparation method of the compound, and the application of the compound in preparation of medicines for therapy of disease and symptoms of respiratory system, wherein the substituted groups in the general formula (I) are defined as the specification.