The invention discloses anti-oil pollutant X-ray radiation-preventing organic glass masterbatch and relates to the technical field of organic glass. The anti-oil pollutant X-ray radiation-preventing organic glass masterbatch comprises the following components in parts by mass: 60-75 parts of methyl methacrylate, 10-20 parts of lead methacrylate, 5-10 parts of lead caprylate, 5-10 parts of fluoroacrylate and 0.05-0.3 part of an initiator. The method comprises the steps: adding the lead methacrylate, the lead caprylate and the fluoroacrylate into the methyl methacrylate for copolymerization; and pouring the mixture into a mold to form the X-ray radiation-preventing organic glass. By adding the lead salt into the organic glass disclosed by the invention, the X-ray radiation-preventing ability of the organic glass can be improved to a great extent; as fluorocarbon bonds have the characteristics of being short in bond, good in stability, small in intermolecular forces and the like, the hydrophobic and oilphobic and anti-pollution abilities of the organic glass can be improved by adding the fluoroacrylate during polymerization. The invention further discloses the method for preparing the organic glass by using the nti-oil pollutant X-ray radiation-preventing organic glass masterbatch.