The invention discloses a piglet intestine nutrition regulation and control feed based on cladded zinc oxide. The complete feed comprises 0.06-0.2wt% of cladded zinc oxide and 0.1-0.2wt% of sodium butyrate. The cladded zinc oxide is prepared by performing cladding on ingredients such as stearic acid, long-chain rice bran oil, silicate and carboxymethyl cellulose sodium by use of an inlaid cladding technology, has the effect of effectively preventing zinc oxide from being acidified into zinc ions and consuming hydrogen ions in piglet stomaches and is capable of improving the activity of pepsin, so that the active ingredient (zinc oxide) efficiently enter into an intestinal tract so as to exert effects of resisting bacteria and protecting intestinal mucosa mucoprotein structure; sodium butyrate has an effect of rapidly supplying energy nutrients to piglet intestine mucous cells, and has a food attractant effect on piglets due to unique smell. Cladded zinc oxide and sodium butyrate can achieve a synergetic effect and exert respective effects of protecting the intestinal mucosa mucoprotein structure and promoting mucosa epithelial cell growth, and the effects of improving the feed intake of weanling piglets and obviously reducing the after-weanling diarrhoea rate. The piglet intestine nutrition regulation and control feed is capable of obviously reducing the diarrhoea rate of weanling piglets and improving the feed intake and growth property of the weanling piglets.