The invention relates to the field of medical apparatus and instruments, and discloses a multi-purpose pricking-wound-preventing apparatus and a use method of the multi-purpose pricking-wound-preventing apparatus. The multi-purpose pricking-wound-preventing apparatus comprises a spine part clamping part, a sleeve, spiral springs and a base, wherein the spine part clamping part is composed of a handle and a plurality of clamping clacks connected with the handle, and all the clamping clacks are annularly arranged and surround to form a spine part insertion hole. Through the mechanical coordination of the sleeve, the springs and the base, the clamping force of the spine part clamping part for the spine parts of various apparatuses, such as needles, burrs of the dental department, and file-expanding needles for machines is controlled, the assembly or disassembly of the spine parts of the apparatuses can be conveniently carried out, meanwhile, the spine parts of the apparatuses are covered by the clamping part, so that the human body is prevented from being punctured, and the safe connection for use of the sharp apparatuses with consumable items, instruments and equipment can be guaranteed, and in addition, the multi-purpose pricking-wound-preventing apparatus can clean the spine parts of the apparatuses, and is simple in structure, convenient to assemble and disassemble, low in cost, and suitable for practical promotion and application.