利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN106620679A 以白介素33为治疗靶点的肿瘤疫苗 审中-实审

以白介素33为治疗靶点的肿瘤疫苗
摘要：
本发明涉及分子生物学及免疫学领域，具体来说是利用呈递白介素33（IL‑33）全蛋白的病毒样颗粒对小鼠进行主动免疫干预,诱导机体产生抗自身IL‑33的特异IgG抗体应答，从而持续下调小鼠体内IL‑33的表达水平，增强机体的抗肿瘤免疫应答，抑制肿瘤生长。
摘要（英）：

The invention relates to the field of molecular biology and immunology. Specifically, active immunity intervention is performed on a mouse with virus-like particles presenting IL-33 (interleukin-33) whole protein to induce the organism to produce specific IgG antibody response resistant to IL-33, so that the expression level of IL-33 in the mouse is decreased continuously, the anti-tumor immunity response of the organism is enhanced, and tumor growth is inhibited.

0/0