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发明公开
CN106632397A 一种6α‑溴青霉烷‑3α‑羧酸二苯甲酯‑1β‑氧化物的制备方法 有权 转让

一种6α‑溴青霉烷‑3α‑羧酸二苯甲酯‑1β‑氧化物的制备方法
摘要：
本发明公开了一种6α‑溴青霉烷‑3α‑羧酸二苯甲酯‑1β‑氧化物的制备方法。该方法以丙酮作为催化剂，二苯甲酮腙在酸性条件下由KMnO4氧化反应生成二苯重氮甲烷的反应液，然后滴入6α‑溴青霉烷‑3α‑羧酸‑1β‑氧化物中得到产物。该方法具有方法简单、使用安全环保、产物纯度高、收率高等优势。
摘要（英）：

The invention discloses a preparation method of 6alpha-bromopenicillanic-3alpha-carboxylic di-methylphenyl-1beta-oxide. According to the method, acetone is used as a catalyst; benzophenone hydrazone takes an oxidation reaction with KMnO4 under the acid condition to generate diazodiphenylmethane reaction liquid; then, the reaction liquid is dripped into the 6alpha-bromopenicillanic-3alpha-carboxylic di-methylphenyl-1beta-oxide to obtain a product. The method has the advantages that the method is simple; the use is safe; the environment-friendly effect is achieved; the product purity is high; the yield is high, and the like. The reaction equation is shown as the accompanying drawing.

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