The invention provides a preparation method for a mold with a wear-resistant coating based on a laser additive manufacturing technology. The method comprises the steps that a mold to be processed and at least two molding powders are provided, the molding powders are respectively transferred to powder feeders to conduct preheating and heat preserving, the molding powders comprises at least powder A and reinforced powder B which are consistent with the mold materials or have similar mold material components; the processing procedures are set, the corresponding molding powders are sent to the radiation position of a laser beam according to the processing procedures, melt and deposited on the surface of the mold, wherein the processing procedures comprise the steps that the mold surface is divided into a plurality processing areas and the adjacent processing areas form a coating generated by melting and depositing of different molding powders; the mold completing laser processing is reprocessed to the target size after heat treatment and a finished mold is obtained. By the adoption of the preparation method, the wear-resistant coating mold with good anti-resistance which is not prone to spalling is easy to prepare, and the problems of short service life of the existing mold and complicated process of the surface strengthening are solved.