利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN106659766A 烯醇酶1(ENO1)组合物及其用途 审中-实审

烯醇酶1(ENO1)组合物及其用途
摘要：
本发明提供了包含用于递送至肌肉的Eno1的组合物。此外，本发明提供了使血糖升高的受试者中的血糖正常化的方法，包括将烯醇酶1(Eno1)施用于受试者，由此使受试者的血糖正常化。本发明还提供了治疗受试者的一种或多种病症的方法，所述病症包括受损的葡萄糖耐量、胰岛素抗性、前驱糖尿病和糖尿病，尤其是2型糖尿病，该方法包括将烯醇酶1(Eno1)施用于受试者，由此治疗受试者的病症。在本发明的特定方法中，将Eno1递送至肌肉。
摘要（英）：

The invention provides compositions comprising Enol for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Enol), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Enol), thereby treating the condition in the subject. In certain methods of the invention, the Enol is delivered to muscle.

0/0