The invention relates to a vehicle remote diagnosis system and method based on an information safety technology. The vehicle remote diagnosis system based on an information safety technology includes a diagnosis target ECU and a remote diagnosis server, and also includes a vehicle diagnosis reception gateway, wherein the vehicle diagnosis reception gateway is arranged between the diagnosis target ECU and the remote diagnosis server, and is in communication connection with the diagnosis target ECU and the remote diagnosis server; an asymmetric encryption unit is arranged between the vehicle diagnosis reception gateway and the remote diagnosis server; a symmetric encryption unit is arranged between the vehicle diagnosis reception gateway and the diagnosis target ECU; the remote diagnosis server communicates with the vehicle diagnosis reception gateway through an asymmetric encryption mode; and the vehicle diagnosis reception gateway communicates with the diagnosis target ECU through a symmetric encryption mode. Compared with the prior art, the vehicle remote diagnosis system and method based on an information safety technology can guarantee anonymity, integrity and authenticity of the whole vehicle remote diagnosis process.