利索-全球专利检索

  1. 登录
  2. 注册
发明授权
CN106699701B 1-O-甲基-2,3-二脱氧-L-阿拉伯呋喃糖的制备方法 有权

1-O-甲基-2,3-二脱氧-L-阿拉伯呋喃糖的制备方法
摘要：
本发明涉及一种1‑O‑甲基‑2,3‑二脱氧‑L‑阿拉伯呋喃糖的制备方法，它以3,4‑二乙酰基‑L‑阿拉伯糖烯和醇为原料，用路易斯酸为催化剂，得到Carbon‑Ferrier重排产物后，再经碱性条件下脱除乙酰基，最后在酸性条件下催化加氢一步得到目标产物。本发明所使用原料及试剂均廉价易得，反应条件温和，反应步骤少，所得1‑O‑甲基‑2,3‑二脱氧‑L‑阿拉伯呋喃糖总收率高，适宜工业化大生产，以满足医药化工领域对中间体1‑O‑甲基‑2,3‑二脱氧‑L‑阿拉伯呋喃糖的需求。
摘要（英）：

The invention relates to a preparation method of 1-O-methyl-2,3-dideoxy-L-arabinofuranose. The method comprises the following steps: preparing a Carbon-Ferrier rearrangement product from 3,4-diacetyl-L-arabinal and alcohol by using a Lewis acid as a catalyst, removing an acetyl group under an alkaline condition, and carrying out catalytic hydrogenation under an acidic condition to obtain the target product through one step. The preparation method has the advantages of cheap and easily available raw materials and reagents, mild reaction conditions, few reaction steps, and high total yield of the obtained 1-O-methyl-2,3-dideoxy-L-arabinofuranose, and is suitable for industrial large-scale production to meet the demands of medicinal and chemical engineering fields for the intermediate 1-O-methyl-2,3-dideoxy-L-arabinofuranose.

公开/授权文献
0/0